The project
Our research group investigates tumor heterogeneity and the tumor microenvironment in high-grade brain malignancies, acute myeloid leukemia (AML), and patient-derived organoids. We use advanced single-cell and spatial transcriptomics to uncover key mechanisms driving disease progression. To support our work, we are looking for a highly skilled and motivated wet lab technician with expertise in molecular and cellular biology techniques.
Your profile
As a wet lab research technician, you will be responsible for:
- A BSc/MSc in Biomedical Sciences, Molecular Biology, or a related field.
- Hands-on experience with molecular and cellular biology techniques.
- Familiarity with NGS-based workflows (e.g., 10x Genomics, Smart-seq, or similar) is a plus.
- Experience working with tissue processing, immunostaining, or organoid culture is highly desirable.
- Excellent organizational skills and the ability to work independently in a research environment.
- Tissue and cell processing – handling patient-derived samples, dissociation, and cell sorting.
- Single-cell and spatial transcriptomics workflows – including sample preparation, library construction, and sequencing.
- Molecular biology techniques – RNA/DNA extraction, qPCR, and Western blot.
- Histology and imaging – sectioning, staining, immunofluorescence, and microscopy.
- Cell culture and organoid models – maintaining and differentiating primary and stem-cell-derived cultures.
- Lab organization – managing reagents, keeping detailed experimental records, and ensuring protocol compliance.
- Excellent written and oral english.
Our job offer
We offer you a stimulating position within a leading research group in the Netherlands, working at the intersection of cancer biology, single-cell genomics, and spatial transcriptomics. You will have the opportunity to engage in cutting-edge translational research on high-grade malignancies, organoids, and leukemia.
You will be appointed to a temporary position for 36 hours per week for the duration of one year. Your gross monthly salary will start in FWG 45, with a maximum salary of €4,015 gross per month for a full-time working week (36 hours). You will also receive 8.33% holiday allowance and an 8.33% end-of-year bonus. Employment conditions follow the collective labor agreement (‘cao ziekenhuizen’).
The Princess Máxima Center
The Princess Máxima Center for Pediatric Oncology is a research hospital concentrating healthcare, research and education with regard to cancer in children in a single location in Utrecht. The institute aims to provide the highest level of care for all children with cancer and has the ambition to cure all children of cancer and significantly reduce unwanted side effects. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.
The Stunnenberg group
Our research focuses on understanding tumor heterogeneity, clonal evolution, and the tumor microenvironment using state-of-the-art single-cell and spatial transcriptomics approaches. Our key areas of investigation include:
High-Grade Brain Malignancies
- We have built a glioblastoma atlas at single-cell resolution, compiling data from multiple studies to create a curated reference map. This resource facilitates cell annotation and hypothesis generation.
- We study cell heterogeneity in pediatric high-grade gliomas, investigating how tumors are organized into distinct cellular communities.
- We explore the local signaling environment between cancer cells and the tumor microenvironment (TME) using spatial transcriptomics.
High-Grade Brain Malignancies
- We are constructing a comprehensive single-cell reference map of human patient-derived organoids and matched primary tissue.
- Our aim is to generate gene expression and open chromatin profiles from the same cell to provide insights into health and disease.
Pediatric and Adult AML
- Acute Myeloid Leukemia (AML) is an aggressive malignancy with a high risk of relapse. We investigate clonal heterogeneity and disease progression using (epi)genomic analysis and single-cell RNA sequencing.
Applying for this position?
Are you excited about this position? We are looking forward to meeting you! You can apply until directly by clicking on the orange button on this page. We invite you to apply as soon as possible, since we will close the vacancy when we have found a suitable candidate.
Please provide:
- an up-to-date resume/CV
- a short motivation letter describing your background and interests
For more information about this position, please contact Henk Stunnenberg. Henk will be happy to tell you more!
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