We are seeking a highly motivated and talented Postdoctoral Researcher with a PhD in genomics, cancer biology, or related fields to join our team and contribute to our ongoing projects in computational genomics.
The Position
The project focuses on dissecting clonal evolution in pediatric acute myeloid leukemia (AML) using a combination of single-cell DNA sequencing (scDNA-seq) and/or long-read sequencing (Nanopore) to resolve complex mutational landscapes and evolutionary trajectories. You will be responsible for:
- Processing and optimizing single-cell DNA workflows
- Applying long-read sequencing (Nanopore) for mutation detection and structural variant analysis.
- Collaborating closely with molecular and computational biologists, translational scientist and clinicians.
This position is embedded in a multidisciplinary team with expertise in pediatric AML, single-cell genomics, and computational biology, providing a stimulating environment for cutting-edge leukemia research.
Qualifications
- PhD in molecular biology, cancer biology, genomics, or a related field
- Wet lab and computational expertise in single-cell DNA sequencing, long-read (Nanopore) sequencing, and library preparation
- Experience with mutation detection, clonal evolution, and single-cell genomics in leukemia or cancer
- Proven research productivity.
- Excellent communication and teamwork skills
- Collaborate and mentor MSc and PhD students
Our job offer
We offer you a full-time position (based on 36 hours a week) in a very stimulating and interactive research environment. You will have access to cutting-edge research facilities. We also offer you a collaborative and supportive work environment with mentorship from experienced researchers. The contract will be initially for one year, with the possibility to extend upon satisfaction. Your gross monthly salary will depend on your experience and background, starting in scale 60 with 8,33% gross monthly salary holiday allowance and 8,33 % end-of-year bonus. The Princess Máxima Center operates according to the collective labor agreement ‘cao algemene ziekenhuizen’.
The Stunnenberg group
Our group combines cutting-edge molecular biology and single-cell genomics to investigate clonal evolution and therapy resistance in pediatric AML. Using single-cell DNA sequencing and long-read (Nanopore) technologies, we dissect the genetic complexity of leukemic clones and track their evolution over time. Relapse remains the leading cause of treatment failure in AML, its molecular drivers are not fully understood. By applying single-cell omics, long-read sequencing, and functional genomics and signaling pathway analyses, we aim to uncover the mechanisms of relapse and inform improved therapeutic strategies.
The Princess Máxima Center
The Princess Máxima Center for Pediatric Oncology is an integrated hospital and research institute, which integrates healthcare, research and education on pediatric cancer, in a single location in Utrecht. Our institute aims to provide the highest level of care for all children with cancer, with optimal quality of life. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.
Contact
You can apply for this position using the apply button. Please provide:
- an up-to-date resume/CV.
- a motivation letter of max. 1 page including description of your qualifications.
- contact information of 2-3 references.
For more information about this position, please contact Henk Stunnenberg. Henk will be happy to tell you more!
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