Research technician with genomics expertise

Kuiper Group

 

Organisation

The Princess Máxima Center for Pediatric Oncology is a recently started, fastly growing research hospital for children with cancer. The institute houses an increasing number of research groups, which aim to develop cures for all children with cancer with minimal long-term side effects of existing treatment. We currently have nearly 300 employees entirely dedicated to research.

The Kuiper group focuses on Childhood Cancer Genetics and Predisposition, and aims to identify and investigate genetic aberrations involved in the process of cancer initiation and progression in order to understand genetic predisposition and disease recurrence. Our research projects focus around two major themes:

  • the genomic aberrations associated with therapy resistance and relapse in leukemia
  • identification of genetic abnormalities associated with cancer predisposition in children and young adults

Our group has strong collaborations with several other research groups within the Princess Máxima Center, as well as with multiple international groups, consortia and networks. Within the group we currently have a vacancy for a research technician.

 

Research Topic

The growing availability of genome-wide profiling and sequencing technologies revolutionizes our understanding of cancer genomes. This knowledge provides us with opportunities to identify patients that are at increased risk for developing cancer and better predict their risks for cancer development. Single gene mutations have been identified with a major impact on cancer risk and outcome. In the majority of cases, however, the cause of cancer onset and progression is dependent on a more complex interplay between genetic factors, which is more challenging to elucidate. We try to unravel this interplay of genetic factors by applying sophisticated analyses of whole genome sequencing and transcriptomics data of both tumor samples and normal inherited DNA, with the ultimate aim to identify novel genes and mechanisms involved in an individual’s risk for cancer development and therapy response.

 

Tasks and responsibilities

You will work on ongoing projects aimed at identifying novel genes associated with cancer predisposition in children, and unraveling the mechanisms involved in cancer initiation and progression in these patients. Our group uses a variety of genomic techniques to detect genomic alterations (mutations, copy number alterations, chromosomal translocations) on genome-wide scale and with high sensitivity. You will closely collaborate with PhD students and postdocs in the group, and you will be involved in organisational tasks that are required to run a research lab. Finally, you will participate in a network of research technicians that coordinate lab-related task in our institute.

 

Education and skills

  • BSc (HLO laboratory research or equivalent) specialization in molecular biology, life sciences or a related field
  • Hands-on experience with genomic (next generation) sequencing techniques
  • Affinity with computer-based data analysis
  • Independent and organized working style
  • Strong communicative skills
  • Flexible, with a great sense of teamwork
  • Eager to learn new techniques
  • Self-critical mindset

 

Working at the Princess Maxima Center for Pediatric Oncology

We offer a full-time position based on 36 hours per week. You will start on a temporary position for the duration of one year that -when satisfactory- will be extended.

Salary is based on salary scales for research technicians depending on years of experience. The Princess Máxima Center operates according to the collective labor agreement ‘cao algemene ziekenhuizen’.

 

Apply for this position?

You can apply for this position until March 1st by pressing the apply button on this screen.

We welcome you to contact Dr. R.P. Kuiper (r.kuiper@prinsesmaximacentrum.nl) for additional information about the vacancy. Detailed information about the Princess Máxima Center for Pediatric Oncology can also be found at www.prinsesmaximacentrum.nl.

Acquisitie naar aanleiding van deze vacature wordt niet op prijs gesteld.

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