The Princess Máxima Center for Pediatric Oncology is a new nationwide research hospital concentrating healthcare, research and education with regard to cancer in children and is located at the Utrecht Science Park de Uithof. The institute has the ambition to give the best treatment to children with cancer with the highest cure rate and the least side effects of (often complex) anti-cancer treatment. The center brings together the best possible care and scientific research, creating a unique comprehensive childhood cancer center in Europe.
The research group of Prof. Monique den Boer (15fte) focusses on the discovery of new (genetic) lesions and targets for precision medicines to improve the clinical outcome for children with acute lymphoblastic leukemia. Our 25-year track record in preclinical/translational research has resulted in knowledge being implemented in new treatment protocols, and our journey continues to further improve the specificity of anti-leukemia treatment. We have expertise in so-called pathobiological studies addressing which (combination of) genetic lesions characterize the patients’ leukemia, how these lesions functionally contribute to therapy resistance and how these lesions affect the behavior of leukemic cells and the interaction with the bone marrow microenvironment. This information is essential to develop strategies that kill leukemic cells more specifically, also given the emerging role for immunotherapeutic strategies like targeting leukemic cells with engineered CAR-T cells.
The research facilities are excellent and state-of-the-art in the new Princess Máxima Center , which opened its doors in 2018 (chief research officer Prof. Hans Clevers). The Den Boer group routinely uses many laboratory techniques including different sequencing platforms, lentiviral transduction procedures, flow cytometry and sorting, CSLM imaging, migration assays, drug cytotoxicity studies, and easily implements new innovative technologies like live cell/organel-tracking, metabolomics and single cell sequencing.
Tasks and responsibilities research technician
Leukemic cells reside in the complex architecture of the bone marrow compartment. We recently discovered that leukemic cells selectively manipulate this microenvironment as survival strategy, using a.o. tunneling nanotubes. The research technician will join the ‘leukemic niche” team and will investigate which molecules are being exchanged between leukemic cells and the supportive tissue, and will determine which factors promote the survival, expansion and resistance to therapeutic drugs of leukemic cells.
Education and skills
We are looking for a molecular trained research technician with a BSc degree in Molecular Life Sciences (HLO) or BSc/MSc degree in Biomedical Sciences or related studies. The technician should preferably have experience in molecular biology and/or cell biology (flow-sorting, imaging). Our group welcomes candidates who are curious and are eager to learn. The candidate should have excellent communicative skills and a good command of the English language. You are enthusiastic to present and discuss your data in workdiscussions.
We offer a research technician position in an inspiring and multidisciplinary research environment. You will initially be appointed for a period of 1 year, with a possible extension to 2 or more years (full-time). Your gross monthly salary will depend on experience and background, starting in scale 45 with 8,33% gross monthly salary holiday allowance and 8,33 % end-of-year bonus. The Princess Máxima Center operates according to the collective labour agreement ‘cao algemene ziekenhuizen’.
Contact and application:
You can apply for this position until July 7th 2019 by pressing the apply button on this screen.
For more information about the job description please contact:
Prof.dr. Monique den Boer (email@example.com)
Detailed information about the Princess Máxima Center for Pediatric Oncology can also be found at www.prinsesmaximacentrum.nl.
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