Research Technician – the Den Boer group

The Princess Máxima Center for pediatric oncology is a new nationwide research hospital concentrating healthcare, research and education with regard to cancer in children and is located at the Utrecht Science Park de Uithof. The institute has the ambition to give the best treatment to children with cancer with the highest cure rate and the least side effects of (often complex) anti-cancer treatment. The center brings together the best possible care and scientific research, creating a unique comprehensive childhood cancer center in Europe.

The research group of Prof. Monique den Boer (12fte) focusses on the discovery of new (genetic) lesions and targets for precision medicines to improve the clinical outcome for children with acute lymphoblastic leukemia. Our 25-year track record in preclinical/translational research has resulted in knowledge being implemented in new treatment protocols, and our journey continues to further improve the specificity of anti-leukemia treatment. We have expertise in so-called pathobiological studies addressing which (combination of) genetic lesions characterize the patients’ leukemia, how these lesions functionally contribute to therapy resistance and how these lesions affect the behavior of leukemic cells and the interaction with the bone marrow microenvironment. This information is essential to develop strategies that kill leukemic cells more specifically, also given the emerging role for immunotherapeutics like targeting leukemic cells with engineered CAR-T cells.

The research facilities are excellent and state-of-the-art in the Princess Máxima Center. The Den Boer group routinely uses many laboratory techniques, mostly applied to primary leukemic cells from patients, including different sequencing platforms, flow cytometry and sorting, CSLM imaging, migration assays, drug cytotoxicity studies, lentiviral transduction procedures, PCR, Western Blot and easily implements new innovative technologies like live cell/organel-tracking, metabolomics and single cell sequencing.


Tasks and responsibilities research technician

In this position you will work with PhD students and postdocs on studying the interaction of leukemic cells with bone marrow niche cells. The technician will also contribute to patients’ sample processing linked to clinical trials to which we contribute and which requires a precise and dedicated working attitude.


Education and skills

We are looking for a molecular trained research technician with a BSc degree in Molecular Life Sciences (HLO) or BSc/MSc degree in Biomedical Sciences or related studies. The technician should have experience in cell culture and basic techniques such as flow cytometry and RTQ-PCR. Preferably also experience in other techniques such as flow sorting and widefield or confocal microscopy. Knowledge about immunology is preferred. Our group welcomes candidates who are curious and are eager to learn. The candidate should have excellent communicative and organizing skills and a good command of the English language. You are enthusiastic to present and discuss your data in work discussions.


We offer

We offer a research technician position in an inspiring and multidisciplinary research environment. You will initially be appointed for a period of 1 year, with a possible extension to 2 or more years (full-time). Your gross monthly salary will depend on experience and background, scale 45 or 50 with 8.33% gross monthly salary holiday allowance and 8.33 % end-of-year bonus. The Princess Máxima Center operates according to the collective labor agreement ‘cao algemene ziekenhuizen’.

 

Contact and application:

You can apply for this position until May 15th 2022 by pressing the orange apply button on this screen. Send your motivation letter and CV stating the vacancy code Den Boer, research technician.

For more information about our group, please visit Den Boer Group . For information or questions about this job opportunity, please contact Aurélie van Kleef-Boeree (a.boeree@prinsesmaximacentrum.nl)

Detailed information about the Princess Máxima Center for pediatric oncology can also be found at www.prinsesmaximacentrum.nl.

Acquisitie naar aanleiding van deze vacature wordt niet op prijs gesteld.

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