Research Technician for genomics, modeling and preclinical research of pediatric brain tumors – Kool group

The Princess Máxima Center for Pediatric Oncology is a new research hospital, which concentrates healthcare, research and education with regard to cancer in children in a single location in Utrecht. The institute aims to provide the highest level of care for all children with cancer and has the ambition to cure all children of cancer and to significantly reduce unwanted side effects. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.

Dr. Marcel Kool and his group are looking for an enthusiastic, highly motivated research technician with experience in cell or organoid culture and molecular techniques to join their research program modeling pediatric brain tumors.

The research group of Dr. Marcel Kool studies the genomics and epigenomics of pediatric brain tumors and how to translate findings from these studies into novel therapies. More effective and less toxic therapies are highly needed as there are many types of childhood brain tumors for which the survival is still very poor or where survivors suffer from serious long-term side effects caused by their intensive therapies. In order to develop such new therapies, we need many preclinical models, molecularly well-characterized, and representing the broad spectrum of different pediatric brain tumor entities and the inter-tumor heterogeneity within each of these entities. We will use these models to get a better understanding of tumor origin and biology and to find new ways how to target them.

Our group is mostly working on ependymomas (EPN) and embryonal brain tumors, which are amongst the most aggressive brain tumors in children. The latter include medulloblastomas (MB), atypical / teratoid rhabdoid tumors (ATRT), embryonal tumors with multilayered rosettes (ETMR), and other tumor types previously called primitive neuroectodermal tumors of the central nervous system (CNS-PNETs). Dr. Marcel Kool is a world leading expert in the classification and molecular characterization of these types of tumors and has published several landmark papers for each of these different entities.

We work in close collaboration with our sister research group, which Dr. Marcel Kool leads at the Hopp Children’s Cancer Center (KiTZ) in Heidelberg, Germany. Both groups are part of these same research program but address different aspects of ependymomas and embryonal brain tumors. The group in Heidelberg works on the genomic and epigenomic analyses of these tumors and how to translate (epi)genomic findings to the clinic using patient-derived xenograft (PDX) mouse models. Our group in Utrecht is developing novel in vitro models for these tumors, using all the knowledge and expertise on organoids that exists at the Princes Máxima Center.  We are generating Genetically Engineered Brain Tumor Organoids (GEBTOs) by introducing tumor-specific mutations in developing brain organoids as well as establishing co-culture and tumoroid models directly derived from patient material. These models will be used in drug screens to find new ways how to treat these tumors as well as they will be used to study the development of the brain tumors in more detail using (single cell) genomic analyses.

Tasks and responsibilities
We are looking for an enthusiastic and meticulous research technician to join our group. You will work in a dynamic team on various projects, with an emphasis on culturing and characterization of new organoid models. You will also support our group by helping with laboratory management.

Education and skills
We are looking for a flexible, curious and motivated team player with a BSc degree in Molecular Life Sciences (HLO) or BSc/MSc degree in Biomedical Sciences, Neuroscience or related studies. You have experience and affinity with cell or organoid culture as well as general molecular techniques, immunochemistry and/or genomics. You have good communication skills and good command of the English language.

We offer
We offer a research technician position in an inspiring and dynamic environment. You will be employed for 36 hours / 5 days a week for an initial period of 1 year, with a possible extension to 2 or more years. Your gross monthly salary will depend on experience and background, starting in scale 45 with 8,33% gross monthly salary holiday allowance and 8,33 % end-of-year bonus. The Princess Máxima Center operates according to the collective labor agreement ‘cao algemene ziekenhuizen’.

Apply for this position?
You can apply for this position until April 23rd 2021 by pressing the orange apply button (solliciteer direct) on this screen.
For more information please contact Dr. Marcel Kool (m.kool-5@prinsesmaximacentrum.nl) and Dr. Jens Bunt (j.bunt-7@prinsesmaximacentrum.nl)

Acquisitie naar aanleiding van deze vacature wordt niet op prijs gesteld.

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