The Dream3Dlab from the Princess Máxima Center is seeking a skilled technician with a passion for organoid technology and high-throughput imaging. As an integral part of our innovative team, you will play a crucial role in providing support for organoid culture and advancing high-throughput imaging techniques.
Responsibilities
- Organoid Culturing: Lead the cultivation and maintenance of organoid models, ensuring their viability and functionality for research purposes.
- High-Throughput Imaging: Operate and maintain high-throughput imaging equipment, facilitating efficient data acquisition and analysis.
- Data Analysis: Perform data analysis on imaging datasets generated from organoid experiments, extracting valuable insights to support research projects.
- Training and Support: Provide training and support to researchers using organoid technology and high-throughput imaging, promoting effective utilization of resources.
- Technological Advancement: Contribute to the development and implementation of new techniques and methodologies to automate organoid culture and high-throughput imaging capabilities.
Profile
We are looking for a candidate who demonstrates a strong interest in organoid technology and possesses the technical skills necessary to excel in high-throughput imaging.
Requirements
- BSc in Molecular Life Sciences (HLO) or BSc/MSc degree in Biomedical Sciences or related studies.
- Prior experience in cell culture and/or organoid culture techniques is required.
- Knowledge and/or experience with immunofluorescence and widefield or confocal microscopy is preferred.
- Experience with high-throughput imaging methods is a strong plus.
- Proficiency in data analysis software and image processing tools.
- Strong communication skills, attention to detail, flexibility and the ability to collaborate effectively with multidisciplinary teams is critical.
- Eagerness to learn and stay updated on advancements in organoid technology and high-throughput imaging techniques.
Our job offer
This position offers the opportunity to work as a research technician for 36 hours per week in a dynamic and collaborative research environment. The initial appointment is for one year with the possibility of extension. Salary will be commensurate with experience and background, starting in scale 45 with a maximum of €3.824 gross a month based on a full-time position (36 hours). Additionally, you will receive a monthly gross salary holiday allowance of 8.33% and an end-of-year bonus of 8.33%. The Princess Máxima Center operates under the collective labor agreement ‘cao algemene ziekenhuizen’.
The Dream3DLab
You will work within a multidisciplinary team at the forefront of advancing immune-oncology strategies for cancer treatment, using the latest developments in imaging and organoid technology. You will be working with immuno-organoid co-cultures and BEHAV3D, a 3D dynamic imaging platform, we recently developed that leverages patient-derived organoid (PDO) technology. BEHAV3D1 captures both inter- and intra-tumoral heterogeneity in T cell targeting response and delineates their dynamic mode of action. In the proposed project, our objective is to advance BEHAV3D into a high-throughput (HT) technology and help develop a novel 3D phenotyping tool based on our previous work2 for evaluating target presence and therefore select upfront the most promising engineered T cell concepts based on target level of expression and spatial coverage. In our team, we value collegiality, enthusiasm, dedication, respect and reliability, which allow us to successfully reach our goals, while creating a stimulating and creative working atmosphere. We are also heavily present in all initiatives of Máxima related to Diversity.
Princess Máxima Center
The Princess Máxima Center for Pediatric Oncology is committed to providing the highest level of care for children with cancer while driving forward scientific research to improve treatment outcomes. By joining our team, you will be part of a dedicated community working towards a common goal of making a meaningful impact in pediatric oncology research.
Contact
You can apply for this position using the apply button. We invite you to apply as soon as possible, since we will close the vacancy when we have found a suitable candidate. The interviews will be scheduled late May. Please provide:
- An up-to-date resume/CV
- A short motivation letter describing your background and interests
- Contact information of 2-3 references
For more information, please contact Amber Zeeman.
1Dekkers, Johanna F., et al. Uncovering the mode of action of engineered T cells in patient cancer organoids. Nature Biotechnology, 2022 https://rdcu.be/dsehd
2van Ineveld, Ravian L., et al. Revealing the spatio-phenotypic patterning of cells in healthy and tumor tissues with mLSR-3D and STAPL-3D. Nature biotechnology, 2021 https://rdcu.be/dsegT
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