The Princess Máxima Center for pediatric oncology is a unique interdisciplinary institute that brings together all the highly complex care, research, and education to provide the best possible care for children with cancer. This concentration and integration of specialized pediatric oncology reflects our mission: to provide a cure and optimal quality of life for every child with cancer. Close cooperation between care and research will lead to more children being cured of cancer, with fewer adverse effects later in life.
The Princess Máxima Center has recently obtained prestigious funding from KFW for the project : “The Corsano EndoWatch; the smart wearable that helps to improve life of patients after treatment for a suprasellar brain tumour.”
Summary of the project
Children and adults with a suprasellar (hypothalamic) brain tumour often have excellent survival, but pooroutcome due to hypothalamic dysfunction (HD). The hypothalamus is an endocrine gland and the key-regulator of our body. It not only regulates the anteriorpituitary gland, but also regulates core body temperature, circadian rhythm, sodium and energy balance. Patients with HD experience chronic fatigue, recurrent headaches and inactivity due to hypothalamic imbalances. Patients develop (morbid) obesity, due to excessive hunger (hyperphagia) and low energy expenditure. Emotional dysregulation can be present. There is currently no treatment for HD. Patients and families urge us for a solution.
Care-givers are overloaded and try to act as the patient’s “external hypothalamus” to early detect and prevent imbalances and help to resist hyperphagia and improve activity. Supportive care can decrease the burden for the patient and its family, but is intensive and expensive. Current medical practice is not making use of the development of new advanced techniques.
What could be the solution?
A smart wearable could act as an “external hypothalamus” and improve quality of life (QoL) by more early detection of hypothalamic imbalances. This wearable must be available 24/7, monitor body temperature, stress, sleep, daily activity, sodium concentration, give distraction for hyperphagia, and have verbal reminders for the visually impaired. This wearable will improve outcome, self-management, and relieve care-givers.
In this project we aim to develop a smart wearable that acts as “external hypothalamus ” for brain tumour survivors with HD, by
- Development of a smart wearable: the Corsano EndoWatch (based on the certified CardioWatch 287-2).
- A pilot study on the feasibility of wearing the EndoWatch.
- A pilot study on the effectiveness of the EndoWatch on body mass index (BMI), hypothalamic imbalances and QoL.
- Development of a technique for continuous sodium measurements, for future add-on to the EndoWatch
This program will co-fund 2 PhD students, of which one will do its PhD project at the Princess Máxima Center, and the other at TU/e in collaboration with the Princess Maxima Center.
For the overall coordination and administration of the Máxima EndoWatch project, the communication with PhD students, their supervisors, and external partners (TU/e and Corsano), we are looking for an experienced Project Manager to join the Máxima EndoWatch team and the research group of Dr Hanneke van Santen, who is the overall coordinator of the Máxima EndoWatch project.
Key responsibilities (included but are not limited to):
- Overall project coordination and administration of the Máxima EndoWatch project
- Communication with PhD students, their supervisors, and external partners
- Prepare and communicate with KWF about deliverables, milestones, reports and finances
- Assist in grant writing and project coordination of other projects that are running in the research group of Hanneke van Santen
- University degree in Biomedical, Life sciences or other relevant area;
- Experience in project management and ideally knowledge of KWF funded projects;
- Ability to keep people on the right track and motivate them where necessary;
- Ability to set goals, adhere to budget and meet deadlines, even if partially dependent on others to do so;
- Ability to collect and analyze information (e.g. documentation and data);
- Ability to multitask, take self-initiative and able to develop creative solutions to (complex) issues;
- Decisive personality, motivated to pioneer and does not run away from difficult decisions;
- Excellent English writing and verbal communication skills are required, in Dutch will be a vital asset.
Working at the Princess Máxima Center
We offer a 0.44 FTE / 16 hrs position (based on 36 hours a week) in a very stimulating and interactive environment for a period of 5 years. The contract will be initially for one year, with the possibility to extend upon satisfaction. Your gross monthly salary will be based on your experience and background within scale FWG 55-60 and will include 8,33% holiday allowance and 8,33 % end-of-year bonus. The Princess Máxima Center operates according to the collective labor agreement ‘CAO ziekenhuizen’.
Contact and application
You can apply for this position by pressing the apply button on this screen. May we invite you to apply as soon as possible, since we will close the vacancy when we have found a suitable candidate. For more information about this position, or to arrange an informal chat, please contact: Hanneke van Santen, overall coordinator of the EndoWatch project.
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