P r o f i e l
|Functie||PhD student “Hematopoietic Stem Cell Tracing”|
|Voor||Princess Máxima Center for Pediatric Oncology|
|Door||Ruben van Boxtel|
The Van Boxtel Group is looking for an enthusiastic, highly motivated PhD student with experience in stem cell culture and interest in hematopoietic stem cell biology.
Van Boxtel Group
The overall aim of our research is to determine why children can develop cancer, and to unravel the consequences of cancer therapy on tissue mutagenesis and second malignancies. Our vision is that fundamental knowledge of the processes that cause cancer will improve diagnostics, facilitate choice of treatment and contribute to the development of effective preventive therapies. In our team, we value collegiality, enthusiasm, dedication, respect and reliability, which allow us to successfully reach our goals, while creating a stimulating working atmosphere.
We are looking for a motivated PhD student with interest in translational hematopoietic stem cell biology. Experience with stem cell culture techniques is required. We offer a multidisciplinary research atmosphere, which combines functional genomics, stem cell biology and bioinformatics.
Hematopoietic stem cell transplantation (HSCT) is a last-resort curative therapy for patients suffering from various, otherwise lethal, diseases. Administration of sufficient numbers of intact HSCs is critical to restore and maintain life-long blood production in these patients. This project aims to quantify the contribution of individual HSCs to blood regeneration upon HSCT in human recipients, and to unravel the consequences of transplantation on HSC long-term genomic integrity. For this, we will determine naturally occurring somatic mutations in single hematopoietic cells of human HSCT recipients by whole genome sequencing, and track back their clonal history using population dynamics. We aim to quantify the number of HSCs that contribute to blood regeneration in human HSCT recipients, to unravel the consequences of transplantation on their long-term genomic integrity, and to identify clinical and molecular pathways guiding HSC engraftment and long-term integrity.
- Master or equivalent degree in biomedical sciences, molecular/cellular biology, or an equivalent thereof, and a clear interest in translational cancer research.
- Experience in stem cell culture techniques.
- Team player who is eager to contribute to our multidisciplinary research.
- Excellent communication and presentation skills.
- Ambition to pursuit a career in science.
The Princess Máxima Center for Pediatric Oncology is a new research hospital concentrating healthcare, research and education with regard to cancer in children in a single location in Utrecht. The institute aims to provide the highest level of care for all children with cancer and has the ambition to cure all children of cancer and significantly reduce unwanted side effects. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.
A temporary, full-time position based on 36 hours per week. You will start on a temporary position for the duration of one year, which –when satisfactory- will be extended for a total of four years. The Princess Máxima Center operates according to the collective labor agreement ‘cao algemene ziekenhuizen’.
Apply for this position?
You can apply for this position until the 15th of March. Potential candidates will be invited for interviews in the last weeks of March.
Contact and application
For more information contact Dr. Ruben van Boxtel (R.vanBoxtel@prinsesmaximacentrum.nl).
Acquisitie naar aanleiding van deze vacature wordt niet op prijs gesteld.Solliciteer direct