PhD student: Development of therapeutic antibodies for pediatric cancers – Janda group

The Princess Máxima Center for Pediatric Oncology is a nationwide research hospital concentrating healthcare, research and education with regard to cancer in children and is located in Utrecht. The institute has the ambition to give the best treatment to children with cancer with the highest cure rate and the least side effects of (often complex) anti-cancer treatment. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.

The recently formed Janda group studies the molecular mechanisms underlying the development, progression and metastatic transformation of osteosarcoma (OS) as well as normal bone formation. OS is an aggressive form of bone tumor that predominantly affects children and young adults. Standard treatment comprises of chemotherapy (pre- and post-operative) and surgical resection. While patients with localized OS have improved outcome, patients with metastatic OS remain to have poor prognosis. The ultimate goal of our research is to develop more effective and less toxic treatments for all children with OS. Our lab takes a multidisciplinary approach and works collaboratively with several research groups at the Princess Máxima Center.


Key Responsibilities:
 

We are seeking a highly motivated, flexible and energetic PhD candidate to join our fast-paced lab and to develop novel antibody-based therapies for OS and other pediatric cancers. This entails the generation of new antibodies and antibody fragments against newly identified cancer-associated antigens, including new neoantigens. Furthermore, you will test and optimize the suitability of these antibodies for fluorescence-guided surgery, immunoPET and anti-tumor therapy, as well as other clinical applications. You will work in a multi-disciplinary team of cell biologists, pediatric oncologists and pediatric surgeons.


Skills and education:
 

  • A MSc degree in biochemistry, molecular biology, protein biochemistry, and structural biology or related disciplines
  • Prior experience in recombinant protein expression in mammalian and/or insect cells, protein purification using the AKTA-FPLC system (affinity and size exclusion chromatography) and protein characterization is required
  • Experience with antibody library technologies (phage and/or yeast display) is desired
  • Strong motivation, attention to detail, strong drive for creative and innovative scientific approaches, and the ability to work in a team is critical
  • Excellent English writing and verbal communication skills are required


Working at the Princess Máxima Centre:
 

  • We offer a challenging PhD project an inspiring and collaborative research environment. The total duration of the project is 4 years (full-time). You will initially be appointed for a period of one year, after which your performance is evaluated and your contract may be extended with three years.
  • Salary is according to FWG 45 increment 6 (for the 1st year, increased to FWG 45 increment 10 in case of renewal). The Princess Máxima Center operates according to the collective labor agreement ‘CAO algemene ziekenhuizen’.


Interested?
 

You can apply for this position till 15. September 2019 by pressing the ‘Solliciteer direct” button on this screen. We welcome you to contact Dr Claudia Janda (C.Y.Janda@prinsesmaximacentrum.nl) for additional information about the vacancy.

Acquisitie naar aanleiding van deze vacature wordt niet op prijs gesteld.

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