The Princess Máxima Center for Pediatric Oncology is a research hospital concentrating healthcare, research and education of pediatric cancer in a single location in Utrecht. The institute aims to provide the highest level of care for all children with cancer and has the ambition to cure all children of cancer and improve quality of life. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.
We are seeking a highly motivated, flexible and energetic data analist or bioinformatician to join the Heidenreich lab. The successful applicant will be an integral part of the lab’s research activities and will work in close collaboration with bioinformaticians and wetlab scientists both within the group and Institute, and with international collaborators. The initial focus will be on processing and analysing next generation sequencing data including the differential expression using bulk RNA-seq and scRNA-seq data, the analysis of differential splicing and of genetic screens such as shRNA and CRISPR screens. An important aspect will be the integration of data from the different platforms to allow the comprehensive interpretation of functional perturbation studies in leukaemia.
The Princess Máxima Centre for Pediatric Oncology is a new research hospital concentrating healthcare, research and education with regard to cancer in children in a single location. The institute aims to provide the highest level of care for children with cancer and has the ambition to cure all children of cancer and significantly reduce unwanted side effects. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.
The Research Group
The research group led by Olaf Heidenreich is focusing on fusion genes as drivers of childhood leukaemia and targets for novel leukaemia-specific therapies. We are pursuing here a two-pronged approach with, on the one hand, developing drug delivery approaches for the direct inhibition of fusion gene expression, and, on the other, exploring the fusion gene-driven transcriptional networks for crucial “transmitters” that are amenable to pharmacologic intervention. In particular the second part includes genome-wide bulk and single cell-based approaches including RNA-seq and ChIP-seq as well as the application of targeted and genome-wide RNAi and CRISPR screens. These studies will be performed in cell lines and patient-derived cells both in tissue culture and in vivo. The ultimate aim of this research is the design of treatments for childhood leukaemia that are more specific, more effective and less toxic than current chemotherapy and transplantation-based regimens to improve both cure of children with leukaemia and their long-term quality of life.
Skills and Education
You are holding BSc or MSc in Bioinformatics, Computational Biology or related disciplines (with an emphasis on data analysis). You have a strong desire to make a difference in the treatment of and outcome for children with cancer. You have excellent bioinformatics and programming skills (Python, R, Java) and experience in the analysis of NGS data including managing and storing large datasets. Moreover, you are keenly interested in applying new bioinformatic tools and pipelines for the analysis of NGS datasets and have a strong motivation for collaboration with wet lab scientists in the team and fellow bioinformaticians. Finally, you are fluent in English and have excellent writing and presentation skills in this language.
Working at the Princess Máxima Center:
We offer an inspiring and interactive research environment, state-of-the-art facilities and possibilities for personal growth and development.
The full-time position (36 hours a week) is initially for one year, with the intention to extend.
Your gross monthly salary will depend on experience and background, starting in scale 45 with 8,33% gross monthly salary holiday allowance and 8,33 % end-of-year bonus. The Princess Máxima Center operates according to the collective labour agreement ‘cao algemene ziekenhuizen’.
You can apply by pressing the orange button “solliciteer direct”on this screen. Application deadline: December 15th 2020.
For more information please contact Prof Olaf Heidenreich (firstname.lastname@example.org).
Acquisitie naar aanleiding van deze vacature wordt niet op prijs gesteld.Solliciteer direct