The Princess Máxima Center for Pediatric Oncology is a new nationwide research hospital concentrating healthcare, research and education regarding cancer in children, and is located in Utrecht. The institute has the ambition to provide the best available treatment to children with cancer, to realize the highest cure rate and diminish the side effects of treatment. The center aims to integrate care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe. At the Trial Office, national and international phase I-IV studies are designed and implemented by a multidisciplinary team of data managers, trial managers, research nurses, statisticians, and members of the medical staff. Investigator-initiated research, as well as research initiated by the pharmaceutical industry, is supported. The Máxima collaborates with the Innovative Therapies for Children with Cancer (ITCC) Consortium, and the Trial Office implements ITCC studies in Europe and elsewhere.

As a statistician you are primarily responsible for the design of (early phase) clinical trials, preparation of statistical analysis sections of protocols, writing of statistical analysis plans, performing analyses and reporting of results, including preparation of manuscripts. In addition, you will give statistical advice to health professionals and researchers, including pharma collaboration, and you will provide statistical support to a variety of medically related studies.

Within the Princess Máxima Center, you will work in a team with other statisticians and other clinical trial related professions. Also, there is a close collaboration with the statistical group of the Clinical Trial Service Unit of the Netherlands Cancer Institute.

Your profile

  • MSc or PhD in statistics, mathematics, econometrics or related discipline;
  • Experience in (early phase) clinical trials is an advantage;
  • Strong knowledge of statistical tools such as SAS and R is required;
  • Knowledge of relevant standards (CDISC, SDTM and ADaM) and regulatory guidelines (e.g. ICH, FDA, and CHMP) is an advantage;
  • Strong communication skills and ability to communicate statistical problems with non-statistical collaborators;
  • Excellent written and spoken English;
  • Willing to travel abroad occasionally.

Your career opportunities and terms of employment
We offer an inspiring and interactive research environment, state-of-the-art facilities and possibilities for personal development and training in statistics, oncology and clinical trials. The gross salary will be according scale FWG 60 of the collective labor agreement for Dutch hospitals (CAO Ziekenhuizen) and can range between EUR 3.225 and EUR 4.682 per month depending on education and previous experience.

For further information please contact:
Prof. dr . Michel Zwaan, PI experimental therapeutics and head of the Trial and Data Center at the Prinses Máxima Center. Phone number secretary: 088-9725206
Dr. Harm van Tinteren, statistician, Head Biometrics Department/ CTSU, Netherlands Cancer Institute, Phone number: 020-5122666

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