Post Doc Drost Group – Bioinformatics or systems biology

In the Netherlands, almost all childhood cancer care and research are concentrated in a single institute, the Princess Máxima Center for Pediatric Oncology. With approximately 600 children per year being affected by cancer in the Netherlands and 150 children suffering from relapse tumors each year, our institute comprises the largest pediatric oncology institute in Europe. This provides a unique opportunity for the Netherlands to contribute to the world-wide effort in understanding and resolving childhood cancer.

The Drost group is looking for an enthusiastic, highly motivated Postdoc with experience in bioinformatics or systems biology.

Background information about the Drost group

The Drost group studies the molecular mechanisms underlying the development of childhood solid tumors. We develop and utilize stem cell culture models, such as organoid technology, in combination with (single cell) omics and lineage tracing approaches to study fundamental processes driving tumorigenesis. Within the group, bioinformatics analyses are an integral part of many research projects, supported by both bioinformaticians within the group as well as through collaborations with other bioinformatics-oriented research groups within the Máxima. In the Drost group, we value collegiality, enthusiasm, dedication, respect, and reliability, thereby creating the most optimal environment to successfully reach our goals.

Within our team, we currently have an opening for a computational biologist with a PhD in bioinformatics or similar experience. We offer a multidisciplinary research atmosphere, which combines bioinformatics, functional genomics, and stem cell biology.

Project

Pediatric malignancies defined by mutations in epigenetic regulators are generally highly aggressive with a low survival rate. As no other genetic driver mutations have been identified, these tumors seem to be primarily driven by derailed epigenetic regulation of gene expression. Yet, how these tumors adapt to changing environmental conditions and treatment is a major unsolved problem frustrating the development of effective treatment approaches. This project aims to study the contribution of (epigenetic) mechanisms to clonal dynamics during tumor progression and therapy resistance. We apply genetic lineage tracing and single cell (epi-) genomics approaches to patient-derived tissues as well as unique organoid stem cell cultures derived thereof. This project involves a unique combination of expertise in bioinformatics, functional genomics, and tumor modelling. Ultimately, it will greatly facilitate international (pediatric) cancer research and lead to improvements in cure rates and quality of life for cancer patients.

Tasks and responsibilities

The candidate will drive forward the bioinformatics research and analyses within this project and will coordinate efforts with other group members and research groups involved in the project to bring it to a successful end. Specific asks and responsibilities include:

  • Take the lead regarding data-driven research questions and ownership of all bioinformatics research aspects within the overall project.
  • Coordinate, design and perform explorative and integrative data analyses (data sets to analyse include bulk and single cell RNA- and ATAC-sequencing data (10X Genomics platform), CUT&RUN sequencing, and targeted DNA barcode sequencing data).
  • Develop new and implement published computational methods.
  • Coordinate the FAIRification of the data generated by the group.

Skills

We expect a highly motivated candidate with a PhD or similar experience in bioinformatics or systems biology. Excellent technical and programming skills are required, preferably in R and Python. Extensive knowledge about analyzing next-generation RNA and DNA sequencing data, single cell omics data, as well as using large-scale computational infrastructures (HPC) are highly recommended. The candidate should also have good communication and problem-solving skills, be independent, flexible and a good team player.

Working at the Princess Maxima Center for Pediatric Oncology

A full-time position (36 hours a week) initially for one year, with the intention to extend for a minimum period of two years as a postdoc. You will be working in a very stimulating and cross-disciplinary research environment, combining cutting-edge technology with state-of-the-art bioinformatics. Your gross monthly salary will depend on experience and background. The Princess Máxima Center operates according to the collective labor agreement ‘cao algemene ziekenhuizen’.

Apply for this position?

You can apply by pressing the ‘Apply’ button on the right of this screen

Application deadline: 30th September

For more information contact Dr. Jarno Drost

Acquisitie naar aanleiding van deze vacature wordt niet op prijs gesteld.

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